49ers All-Pro Deebo Samuel has ankle, knee sprains, expected to return during regular season

The San Francisco 49ers announced Monday that wide receiver Deebo Samuel has ankle and MCL sprains after being injured Sunday, but they anticipate he'll return during the regular season.

Samuel sustained the injury during the second quarter of Sunday's 35-7 win over the Tampa Bay Buccaneers. His left ankle and leg got rolled underneath an opponent's body, and he writhed on the ground in pain after the injury.

Samuel left the field on a cart, leading to speculation that he sustained a significant knee or leg injury. News of his expected return this season is certainly welcome in San Francisco.

The 49ers also announced Monday that quarterback Brock Purdy is considered day-to-day with oblique and rib injuries sustained Sunday. He was listed as limited on an estimated practice report for Monday. The 49ers recently signed veteran journeyman quarterback Josh Johnson, who would presumably start Thursday against the Seattle Seahawks in the event that Purdy can't play.

Purdy completed 76.1% of his passes for 185 yards with two touchdowns and no turnovers in Sunday's win, his second appearance in relief of injured starter Jimmy Garoppolo. The 49ers have won six straight games and hold a two-game lead over the Seahawks in the NFC West, with a 9-4 record.

With four games remaining on the schedule, the 49ers didn't offer a precise timeline for Samuel's expected return. They conclude the regular season with games against the Seahawks, Washington Commanders, Las Vegas Raiders and Arizona Cardinals.

Samuel, 26, is coming off his best season as a pro, having tallied 1,405 receiving yards, 365 rushing yards and 14 total touchdowns during a 2021 All-Pro campaign. In 12 games this season, he has 54 catches for 612 yards, 228 rushing yards and five total touchdowns. He's an invaluable offensive weapon on a team that leans on his playmaking ability, especially after losing its top two quarterbacks to injury in Garoppolo and Trey Lance.

SANTA CLARA, CALIFORNIA - DECEMBER 04: Deebo Samuel #19 of the San Francisco 49ers looks on from the sidelines prior to the start of the game against the Miami Dolphins at Levi's Stadium on December 04, 2022 in Santa Clara, California. (Photo by Thearon W. Henderson/Getty Images)
Deebo Samuel is expected to return during the regular season. (Thearon W. Henderson/Getty Images)