President Joe Biden, who has moved away from predecessor Donald Trump's hard-line immigration approach, gave Harris the job of leading U.S. efforts with Mexico and Central America's Northern Triangle countries - Honduras, El Salvador and Guatemala - to stop migrants from crossing into the United States.
The meeting, which was held virtually, was Harris' second conversation with Guatemala's leader in less than a month - a sign of the best opportunity she has to build a partnership in the region. She previously spoke with him on March 30th.
Harris has yet to speak with leaders of Honduras and El Salvador.
"We want to work with you... in a way that will bring hope to the people of Guatemala, that there will be an opportunity for them if they stay at home," Harris said, adding that she will visit the region in June.