The shooting occurred Thursday morning around 8 am. A shootout took place between agents and the suspects approximately 144 miles off the coast of Cabo Rojo in Puerto Rico, according to the Associated Press.
The wounded agents were airlifted to the Puerto Rico Trauma Centre, officials said.
CBS News reports that one of the agents shot has died, citing a statement given by Secretary of Homeland Security Alejandro Mayorkas.
“Ranking Member [Rob] Portman mentioned the tragic loss of one of our front-line personnel. Several others were gravely wounded. I was briefed on the situation very early this morning. These are brave members of our Air and Marine Operations within U.S. Customs and Border Protection,” he said on Thursday.
It is still unclear who shot at the agents and why.
The conditions of the two wounded agents is currently unknown.