Thousands of protesters gathered despite a threat from authorities that confrontation could cost lives.
Three weeks after seizing power, the junta has failed to stop daily protests and a civil disobedience movement calling for the reversal of the Feb. 1 coup and release of elected leader Aung San Suu Kyi.
In a country where dates are seen as auspicious, protesters noted the significance of the date 22.2.2021, comparing it to demonstrations on Aug. 8 1988 when a previous generation staged anti-military protests which were bloodily suppressed.
At least three protesters have now been killed after two were shot dead in the second city of Mandalay on Saturday and a young protester died in hospital on Friday after getting shot earlier.
One policeman died of injuries in protests, the army has said.