STORY: The stunt directed at "The Sower" was carried out by four women from the group Ultima Generazione (Last Generation) who shouted slogans against global warming and fossil fuels.
"We shouldn't get angry about a painting that is protected by glass and will be clean tomorrow and we don't get angry because we don't know that we are losing food and water," one of the protesters said during the protest.
"The Sower" is part of an exhibition at the historic Palazzo Bonaparte in Rome's city center.
The painting, on loan from the Kroeller-Mueller Museum in the Netherlands, was protected by a glass screen and did not suffer damage, said Camilla Talfani, a spokesperson for the exhibition organizers.
Climate change protesters threw soup over Van Gogh's painting "Sunflowers" at London's National Gallery last month, causing minor damage to the frame.