Welsh goalkeeper Wayne Hennessey was sent off in the 86th minute for a cynical challenge before the Iranians pounced with the late goals.
Gareth Bale, in his record 110th appearance for his national team, failed to inspired Wales.
With the victory, Iran managed to recover from a humiliating loss against England in their opener. Wales, on the other hand, looked tired after their draw with the United States.
Wales' goalkeeper Wayne Hennessey, right, makes a save in front of Iran's Mehdi Taremi during the World Cup group B football match between Wales and Iran, at the Ahmad Bin Ali Stadium in Al Rayyan , Qatar, Friday, Nov. 25, 2022. (AP Photo/Manu Fernandez)
Referee Mario Alberto Escobar Toca shows a red card to Wales' goalkeeper Wayne Hennessey during the World Cup group B football match between Wales and Iran, at the Ahmad Bin Ali Stadium in Al Rayyan , Qatar, Friday, Nov. 25, 2022. (AP Photo/Manu Fernandez)
Iran's Rouzbeh Cheshmi scores his side's opening goal during the World Cup group B football match between Wales and Iran, at the Ahmad Bin Ali Stadium in Al Rayyan , Qatar, Friday, Nov. 25, 2022. (AP Photo/Manu Fernandez)
Iran's Ramin Rezaeian celebrates with teammates after scoring his side's second goal during the World Cup group B football match between Wales and Iran, at the Ahmad Bin Ali Stadium in Al Rayyan , Qatar, Friday, Nov. 25, 2022. (AP Photo/Manu Fernandez)
Wales' Gareth Bale reacts after Iran's Ramin Rezaeian scoring his side's second goal during the World Cup group B football match between Wales and Iran, at the Ahmad Bin Ali Stadium in Al Rayyan , Qatar, Friday, Nov. 25, 2022. (AP Photo/Manu Fernandez)
Senegal netted two goals in the 41st and 48th minutes before Qatar struck back in the 78th minute. The Lions of Teranga restored the lead, and claimed all three points, with an 84th-minute goal.
Senegal's Boulaye Dia scores his side's first goal during the World Cup group A football match between Qatar and Senegal, at the Al Thumama Stadium in Doha, Qatar, Friday, Nov. 25, 2022. (AP Photo/Thanassis Stavrakis)
Qatar's Mohammed Muntari, front, celebrates after scoring his side's opening goal during the World Cup group A football match between Qatar and Senegal, at the Al Thumama Stadium in Doha, Qatar, Friday, Nov. 25, 2022. (AP Photo/Darko Bandic)
Senegal's Famara Diedhiou celebrates after scoring his side's second goal during the World Cup group A football match between Qatar and Senegal, at the Al Thumama Stadium in Doha, Qatar, Friday, Nov. 25, 2022. (AP Photo/Thanassis Stavrakis)
Temmates celebrate with Senegal's Bamba Dieng after he score their third goal against Qatar during a World Cup group A football match at the Al Thumama Stadium in Doha, Qatar, Friday, Nov. 25, 2022. (AP Photo/Petr Josek)
Soccer Football - FIFA World Cup Qatar 2022 - Group A - Qatar v Senegal - Al Thumama Stadium, Doha, Qatar - November 25, 2022 A Qatar fan looks dejected in a stand after the match REUTERS/Amr Abdallah Dalsh
Netherlands 1 - 1 Ecuador
The Netherlands seized an early lead with a Cody Gakpo strike but Ecuador levelled the score with an Enner Valencia goal in the 49th minute.
The Dutch and Ecuadorians are co-leaders in Group A with Senegal also vying for a place in the last 16.
Cody Gakpo of the Netherlands, left, scores the opening goal during the World Cup group A football match between Netherlands and Ecuador, at the Khalifa International Stadium in Doha, Qatar, Friday, Nov. 25, 2022. (AP Photo/Natacha Pisarenko)
Ecuador's Enner Valencia reacts after scoring his side's first goal during the World Cup group A football match between Netherlands and Ecuador, at the Khalifa International Stadium in Doha, Qatar, Friday, Nov. 25, 2022. (AP Photo/Natacha Pisarenko)
Cody Gakpo of the Netherlands, second left, celebrates after scoring the opening goal during the World Cup group A football match between Netherlands and Ecuador, at the Khalifa International Stadium in Doha, Qatar, Friday, Nov. 25, 2022. (AP Photo/Themba Hadebe)
Ecuador's Enner Valencia celebrates with teammates after scoring a goal during the World Cup group A soccer match between Netherlands and Ecuador, at the Khalifa International Stadium in Doha, Qatar, Friday, Nov. 25, 2022. (AP Photo/Natacha Pisarenko)
The result saw the Three Lions failed to assert their status as favourites over the Americans in three World Cup meetings now.
US supporters sing the national anthem prior to the World Cup group B football match between England and The United States, at the Al Bayt Stadium in Al Khor, Qatar, Friday, Nov. 25, 2022. (AP Photo/Julio Cortez)
Weston McKennie of the United States reacts with the ball during the World Cup group B football match between England and The United States, at the Al Bayt Stadium in Al Khor , Qatar, Friday, Nov. 25, 2022. (AP Photo/Julio Cortez)
England's Harry Kane, center left, jumps for the ball with Tim Ream of the United States during the World Cup group B football match between England and The United States, at the Al Bayt Stadium in Al Khor , Qatar, Friday, Nov. 25, 2022. (AP Photo/Luca Bruno)
England's goalkeeper Jordan Pickford clears the ball during the World Cup group B football match between England and The United States, at the Al Bayt Stadium in Al Khor, Qatar, Friday, Nov. 25, 2022. (AP Photo/Hassan Ammar)
Goalkeeper Matt Turner of the United States saves during the World Cup group B football match between England and The United States, at the Al Bayt Stadium in Al Khor , Qatar, Friday, Nov. 25, 2022. (AP Photo/Ashley Landis)
England supporters on the stands during the World Cup group B football match between England and The United States, at the Al Bayt Stadium in Al Khor , Qatar, Friday, Nov. 25, 2022. (AP Photo/Ashley Landis)
Pamela Sumpter, was raped and stabbed, and her brother John Sumpter was stabbed to death, at their Georgia home on July 15, 1990. Andrea Cavallier reports
A controversial spiritual leader in Nepal known as “Buddha Boy” has been sentenced to a 10-year prison term Monday for sexually assaulting a minor, court officials said. Ram Bahadur Bamjan — believed by some to be the reincarnation of the founder of Buddhism — was also ordered to pay $3,700 in compensation to the victim by a judge at the Sarlahi District Court in southern Nepal. The man will have 70 days to appeal against the court order, court official Sadan Adhikari said.
Prosecutors in Australia said Sakina Muhammad Jan forced her daughter to marry a man she didn't want to wed in November 2019, weeks before he killed her