STORY: The Islamist militant group Hamas has claimed the slain gunman from Hebron as its member.
Itamar Ben-Gvir, a far-right politician from the settlement, whose Religious Zionism party is projected to place third in Israel's election on Tuesday, was unharmed.
A settlement spokesperson said four Jews were wounded in the shooting near a checkpoint in Hebron. One of them, a middle-aged man, was later declared dead. It was not immediately clear if he held Israeli citizenship.
Israel's Magen David Adom ambulance service said a Palestinian was also lightly wounded in the incident.
The Palestinian Red Crescent ambulance service said one of its crew members in Hebron was hit in the shoulder by Israeli gunfire. The Israeli military had no immediate comment on that.