Titled Bliss, the film is written and directed by Mike Cahill and also stars See actress Nesta Cooper.
Its official synopsis reads: "Bliss is a mind-bending love story following Greg (Owen Wilson) who, after recently being divorced and then fired, meets the mysterious Isabel (Salma Hayek), a woman living on the streets and convinced that the polluted, broken world around them is nothing but a computer simulation.
"Doubtful at first, Greg eventually discovers there may be some truth to Isabel's wild conspiracy."
Ahead of its launch on Amazon Prime Video on February 5, the three-minute trailer follows the pair as they shift between worlds, with Wilson's character Greg confused about which world is the real one.
"It's almost like a trick being played," he says in the promo, which also shows the characters exhibiting seemingly telekinetic abilities.
At one point, they send a whole room of roller-skaters to the ground, while Greg is able to crunch car metal by simply closing his fist.
The film marks the latest project for Wilson, who has recently been filming a new romantic comedy with Jennifer Lopez.
Bliss will stream from February 5 on Amazon Prime Video.
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