If you want to receive twice-daily briefings like this by email, sign up to the Front Page newsletter here. For two-minute audio updates, try The Briefing - on podcasts, smart speakers and WhatsApp. Fears Macron may torpedo agreement at last moment It is crunch time. Brexit talks are heading for a showdown between Boris Johnson and Emmanuel Macron this weekend, with the prospect of an EU deal dependent on French access to fish in British waters. Senior Downing Street sources are unsure as to whether the French president might "torpedo" the proposed deal at the last moment. There were hopes yesterday that a deal was about to be agreed, but Brussels Correspondent James Crisp says the British delegation was taken aback after the EU made a series of "destabilising" last-minute demands. These are the sticking points. Camilla Tominey predicts there will be no vaccine against the ire of Red Wall Tories if they sense a "sell-out" to Brussels. NHS staff lose vaccine priority as supply fears hit NHS front-line staff will no longer be prioritised for the Covid vaccine, amid confusion over the number of doses that will arrive by the end of the year. Chris Hopson, the chief executive of NHS Providers, said that an initial 800,000 doses "could be the only batch we receive for some time". Last night, the first Pfizer vaccines arrived in Britain. They were delivered to a secure Public Health England depot where they will undergo further checks before being delivered to 50 designated hospital hubs across the four nations. It came as it emerged that people who get the jab will not be exempted from self-isolation if they are contacted by Test and Trace. Although the vaccine gives recipients immunity, scientists do not know if it stops them being carriers. Science Editor Sarah Knapton answers your questions. Meanwhile, America's most senior medical adviser rowed back on claims that the UK moved too fast to authorise the vaccine. Dr Anthony Fauci insisted he was not implying sloppiness on the part of British authorities, in whom he had "great faith". A vaccine might be imminent, but Covid's seismic change to our behaviour means we might not flock back to sports stadiums and theatres even when we have had the jab. If we will all be wearing masks for years to come, Harry de Quetteville asks: Will we ever return to the "old normal"? And Matt is inspired by the vaccine for today's cartoon. More snow expected as temperatures drop to -10C Parts of Britain will continue to see "significant snow" over the next 24 hours and could experience the lowest overnight temperatures of the year. The Met Office warned that icy conditions could cause showery rain to fall as sleet or snow in parts of southern England today. In parts of Scotland, overnight temperatures could drop to an icy minus 10C (14F). View the latest UK weather forecast for today and the weekend. At a glance: More coronavirus headlines 'Overzealous' | Police argue with pub landlords over Scotch eggs Quarantine | Business travellers will no longer have to self-isolate Travel | Christmas railway works are 'too vital to be delayed' Father Christmas | 'Top of list', but no need for Santa to have jab Poetry | Author Julia Forster wins Telegraph's lockdown contest Also in the news: Today's other headlines Royals | The Queen is mourning the loss of one of her dorgis, which died at Windsor Castle - leaving her with just one remaining dog. The death of Vulcan, a Pembroke Welsh Corgi and dachshund mix, means the Queen has one pet, Candy, also a dorgi. Two years ago, the monarch appeared on the cover of Vanity Fair with the four dogs she had at the time. Explosion | Victim found 500ft away after four die at waste plant Epstein | Bill Clinton did visit private island, former aide says Immigration | Murderers and rapists could be barred from asylum Climate | Half of all cars must be electric by 2030 to reach goals News quiz | Where will Queen and Prince Philip spend Christmas? Around the world: Safe at last in Indonesia Kukar, a five-year-old male orang-utan, clings to one of its liberators as it is taken to safety after being found in Indonesia by members of the charity International Animal Rescue. It was being held in captivity as a pet with a rope round its neck. View a gallery of more world pictures.