The incident at the property in Mooresville, a town north of Charlotte, resulted in the death of 61-year-old Robert Farley, reported the Queen City News.
The injured person, a male who was not immediately identified, was transported to Atrium Health Carolinas Medical Center with non-life-threatening injuries.
The body of Farley, who was staying at the home at the time of the incident, was recovered from the debris by first responders, the paper added.
Caleb Farley, a defensive back for the Tennessee Titans, was seen at the 6,300sq-ft property talking to police following the explosion.
Aerial video of the scene showed that the home, which is near Lake Norman, had been reduced to rubble.
Caleb Farley, 24, played college football at Virginia Tech and was a first-round pick of the Titans in 2021.
Neighbours told QCN that they heard a “loud explosion” and that they smelled gas in the area.
“A loud boom, about five minutes to midnight,” recalled Clay Wild, who was out for a morning walk when the incident took place. “A gorgeous house, in all respects, I can’t believe it.”
County records show that the home was listed for more than $2m in 2022 and was built in 2016.
Authorities say there is no suggestion of foul play and an investigation is underway.