Multiple myeloma: What to know about the cancer after death of 'Max Payne' voice actor James McCaffrey
It was estimated around 3,900 Canadians would be diagnosed with myeloma in 2023.
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American actor James McCaffrey has died at the age of 65 after a battle with cancer, according to Variety.
Best known for voicing Max Payne in the popular video game series, and recently Alex Casey in "Alan Wake 2," McCaffrey was diagnosed with multiple myeloma.
He is being remembered for his talent and kindness by fans and those in the film and gaming industries.
I’m heartbroken to hear the sad news of James McCaffrey’s passing. We worked together for more than 25 years. He was a lovely man and a dear friend. He was a key part of the Remedy family. He was a brilliant actor. No one could do what he did better than him. (1/2) pic.twitter.com/JLcEIMUT43
— Sam Lake (@SamLakeRMD) December 18, 2023
Heartbreaking news today about the passing of James McCaffrey.
Such an iconic performer across Max Payne and the Remedy-verse.
He was always so kind and generous in person, and always seemed especially proud to be working in games. pic.twitter.com/OfywxBot8W— Geoff Keighley (@geoffkeighley) December 18, 2023
TMZ first reported the news of his death, saying he succumbed to multiple myeloma.
In Canada, it was estimated that in 2023, around 3,900 Canadians would be diagnosed with myeloma — and 1,700 will die from it.
But what exactly is this form of cancer, and what are the risks of it? Here's what you need to know.
What is multiple myeloma?
Multiple myeloma, or myeloma, is a type of blood cancer associated with the abnormal behavior of plasma cells—white blood cells responsible for antibody production, according to Myeloma Canada and the Canadian Cancer Society.
In the bone marrow, these abnormal plasma cells "interfere with the production of normal healthy blood cells in the bone marrow and overproduce inactive clones of abnormal antibodies." This overproduction affects various parts of the body, such as the bones and kidneys.
The cause of myeloma remains unknown, the sources explained.
Myeloma doesn't form as a lump or tumor. Instead, its cells multiply in the bone marrow, disrupting the production of healthy blood cells. This impacts various bone marrow-active areas in the body, leading to symptoms in bones.
There is no cure for myeloma.
It follows a relapsing-remitting pattern, alternating between periods of symptomatic disease requiring treatment and stable disease controlled by treatment (remission). A relapse occurs when myeloma becomes active again after a treatment period.
What are the signs and symptoms of myeloma?
Multiple myeloma may not manifest symptoms in its early stages. Common signs include:
bone pain
weakness and fatigue
frequent infections
kidney problems
abnormal protein levels in blood or urine
weight loss
nervous system problems
dehydration and extreme thirst
The acronym CRAB is used to denote key symptoms: high blood calcium level (hypercalcemia), renal insufficiency (kidney problems), anemia, and bone disease.
What are the risks of multiple myeloma?
Myeloma Canada explained the cancer develops "when genetic 'errors' occur in the DNA of plasma cells... causing them to multiply uncontrollably and overproduce one type antibody (immunoglobulin)."
While most cancers develop due to a range of risk factors, multiple myeloma can develop in people with no identifiable risks at all, according to the Canadian Cancer Society. Men are at higher risk than women, however.
Other known risks include:
history of monoclonal gammopathy of undetermined significance or MGUS (a plasma cell disorder)
family history of myeloma
obesity
farming (occupational exposure)
weakened immune system (as seen in HIV/AIDS or after organ transplant)
Some autoimmune conditions, viral infections and specific occupations with exposure to certain chemicals can also pose a higher risk, though research is still lacking.
Awareness, early detection and a collaborative approach between patients and healthcare providers remain crucial in managing this blood cancer, sources explained.
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