Russian second seed Daniil Medvedev and Canadian teen qualifier Leylah Fernandez will have afternoon quarter-final matches on Tuesday at the US Open.
Medvedev, this year's Australian Open runner-up, will attempt to reach his fourth Grand Slam semi-final and third in a row at the US Open when he plays 117th-ranked Dutch qualifier Botic Van de Zandschulp in the opener at Arthur Ashe Stadium.
The Russian was the 2019 US Open runner-up and reached the semi-finals last year on the New York hardcourts.
Fernandez, who turned 19 on Monday, will follow by facing Ukraine's fifth-seeded Elina Svitolina after stunning defending champion Naomi Osaka and three-time Grand Slam champion Angelique Kerber in the past two rounds.
In the night session, second-seeded Aryna Sabalenka of Belarus will meet Czech eighth seed Barbora Krejcikova, the reigning French Open champion.
Sabalenka made her deepest Slam run into July's Wimbledon semi-finals.
The final match on Ashe sends Spanish 18-year-old Carlos Alcaraz, who upset Greek third seed Stefanos Tsitsipas, against Canadian 12th seed Felix Auger-Aliassime. The winner will advance to his first Slam semi-final.