On Monday, the former co-stars reunited in a new post to Aniston's Instagram to promote a new line of "Friends" merchandise for a good cause.
In the clip, Aniston, 53, and Cox, 57, are wearing white and black T-shirts that read "Friends forever," along with six keys representing each of the six friends in the iconic sitcom.
"Friends forever," Aniston captioned the post.
The "Morning Show" star also tagged two non-profit organizations, Americares and EBMRF, who will "benefit" from a portion of the proceeds from sales.
Americares helps provide medicine and medical supplies to those in need, while EBMRF aims to raise awareness and find a cure for epidermolysis bullosa, a rare genetic skin disorder.
The reunion sent "Friends" fans into overdrive, with many praising the "soul sisters" for their longtime friendship.
"Friends forever," one follower wrote.
“You guys are perfect together,” another said, while another added that the pair were “friendship goals.”
This isn't the first time that the former castmates have reunited since "Friends" ended in 2004.
Last year, HBO Max released an unscripted "Friends" reunion special that also included Lisa Kudrow (Phoebe Buffay), Matthew Perry (Chandler Bing), David Schwimmer (Ross Gellar), and Matt LeBlanc (Joey Tribbiani).
"It was an incredible time," Cox, who played Monica Gellar, said during the reunion about her time on the sitcom, adding how thankful she is for her lifelong friends.
"Everything came together. We became best friends through just the chemistry, the whole thing. It was life-changing and it forever will be - not just for us, but for people who watch it, and that's such a great feeling to carry forever," she continued. "I'm really thankful, and I love you guys so much."