The Jaguars fought back from a 10-nil deficit in the second quarter, with a 25-yard pass from quarterback Trevor Lawrence to wide receiver Christian Kirk scoring the first of two touchdowns.
The second, and winning, touchdown was achieved by outside linebacker Josh Allen with an impressive 37-yard fumble return which brought the Jaguars from seven points behind to a four-point win.
Meanwhile, the Kansas City Chiefs defeated the Las Vegas Raiders 31-13.
It was a momentous game for the Chiefs, who secured the AFC’s top seed, while quarterback Patrick Mahomes set an NFL record for total yards in a season, with 5608.
Ahead of the game, the Chiefs and Raiders held a moment of support for hospitalised Buffalo Bills safety Damar Hamlin, with applause and cheers around the Allegiant Stadium.