While specific plot details have not yet been revealed, we now know that Sacha's behaviour will spiral in response to Essie's tragic death, and his colleagues will grow concerned when they spot him with his ex-patient Jodie (Reece-Williams).
Reece-Williams starred as Genesis Walker on Emmerdale from 2008 to 2013. Some of her other credits include Line of Duty, Requiem and Hidden.
Having been off-air for nearly three months, the medical soap has now confirmed that it will return to BBC One on Tuesday, November 10 at 8.15pm.
The final episode before Holby's hiatus saw Sacha and Essie decide to bring their wedding forward, in fear that the latter would pass away before they had chance to tie the knot.
Essie had previously been diagnosed with terminal cancer and was making preparations for the end of her life.
She delighted Sacha by telling him she wanted to get married there and then, but unfortunately she didn't make it down the aisle.
As Fletch wheeled her from her ward to the chapel, he was devastated to realise that she'd died peacefully on the way. Fletch then had the horrible task of breaking the news to Sacha, who was waiting for her at the altar.
Holby City airs on BBC One.
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