The ITV show released a teaser clip ahead of Winkleman's appearance on Saturday (11 March), which showed her in Ikea quizzing a staff member about chopping boards.
The TV star was on the verge of laughing from the outset, starting to chuckle uncontrollably when all Ant and Dec had asked her to do was ask a staff member for some help.
"She's laughing already!" exclaimed Dec, as he and his presenting partner watched what was going on from a secret room.
As the presenters told Winkleman to ask for different types of boards, she could barely keep it together.
Starting to laugh she had to turn away from the unsuspecting shop employee and hide her face as she took some breaths in a bid to control herself.
Ant and Dec were tickled as she quizzed the baffled worker further and tried to explain to him that she was after a cork chopping board.
They both roared with laughter as they realised she couldn't stop laughing.
"She can't do it!" giggled Dec.
Ant and Dec's Saturday Night Takeaway return to TV screens in February.
The next instalment of the much-loved show airs on Saturday (11 March) night on ITV1 and ITVX at 7pm.
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