The 21-year-old Draper took the second set against the defending champion before fading in a 7-5 2-6 6-4 6-1 defeat while Raducanu put concerns over an ankle injury behind her to set up a clash with Coco Gauff.
Women’s top seed Iga Swiatek battled past Jule Niemeier but the tournament lost one of its biggest names as Nick Kyrgios pulled out with a knee injury ahead of his scheduled first-round match.
Picture of the day
Quote of the day
I'm devastated, obviously. It's my home tournament. I've had some great memories here.
Kyrgios on his withdrawal
Breaking new ground
The 17-year-old is one to watch in Melbourne this week.
Curse of Netflix?
It has been impossible to escape the launch of Netflix’s behind-the-scenes documentary series Break Point at Melbourne Park. But players may think twice about taking part in future editions given three of the main protagonists – Paula Badosa, Ajla Tomljanovic and Kyrgios – have now withdrawn from the tournament through injury.
There was a bizarre moment during the first set on Rod Laver.
Raducanu nutty about coconut water
Raducanu has arrived at both her press conferences at Melbourne Park so far drinking from a coconut. She revealed it was love at first sip, saying: “It’s so good. I used to hate coconuts actually until the Australian Open last year, and then I had it and it’s a game changer.”
Women: Marie Bouzkova (25), Amanda Anisimova (28)Men: Lorenzo Musetti (17), Borna Coric (21)
Who’s up next?
Andy Murray will try to cause an upset on Rod Laver Arena on Tuesday when he takes on 13th seed Matteo Berrettini.
Dan Evans is the other British player in action against Argentina’s Facundo Bagnis while Novak Djokovic will test out his troublesome hamstring in the night session when he meets Roberto Carballes Baena.
Second seeds Casper Ruud and Ons Jabeur are also in action and fifth seed Andrey Rublev plays former finalist Dominic Thiem.