The contest lasting five hours and 45 minutes finished at 4.05am and ended a day that saw defeats for second seeds Casper Ruud and Ons Jabeur and more hamstring concern for Novak Djokovic.
Dan Evans moved safely through to round three 15 hours before Murray completed victory to set up a clash with fifth seed Andrey Rublev.
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I am worried. I cannot say that I'm not. I have reason to be worried.
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Not so lucky day
Alexander Zverev won the first set against Michael Mmoh but went on to lose after this unfortunate interruption.
Women: Ons Jabeur (2), Veronika Kudermetova (9), Anett Kontaveit (16), Liudmila Samsonova (18), Irina Camelia Begu (27)Men: Casper Ruud (2), Taylor Fritz (8), Alexander Zverev (12), Pablo Carreno Busta (14), Diego Schwartzman (23), Alejandro Davidovich Fokina (30)
Who’s up next?
Cameron Norrie will bid to reach the fourth round for a third straight grand slam when he takes on talented young Czech Jiri Lehecka.
Women’s top seed Iga Swiatek will look to avoid the raft of upsets against Spanish qualifier Cristina Bucsa while third seed Jessica Pegula plays Ukrainian Marta Kostyuk.
Stefanos Tsitsipas, now the highest-ranked man left in the draw, takes on Tallon Griekspoor, and Mackenzie McDonald will look to follow up his upset of Rafael Nadal by taking out 31st seed Yoshihito Nishioka.