Antetokounmpo received 75 first-place votes and 432 points in balloting performed by a panel of 100 sportswriters and broadcasters. Power forward Anthony Davis of the Los Angeles Lakers was second (200 points, 14 first-place votes) and Utah Jazz center Rudy Gobert (187, six) finished third.
Gobert won the award in each of the previous two seasons. Antetokounmpo finished second in last season's balloting.
Statistics toward consideration for the award were used through March 11, the night the NBA season was suspended after Gobert tested positive for COVID-19 prior to a game at Oklahoma City.
Antetokounmpo averaged 13.7 rebounds up to that point -- including an NBA-leading 11.5 on the defensive end -- as well as 1.04 steals and 1.02 blocked shots per game.
"His commitment to defending and his commitment to winning is beyond incredible," Bucks coach Mike Budenholzer said on TNT. "He impacts the game with his blocked shots, his rebounding, his ability to guard all five positions ... his talent is beyond special."
Antetokounmpo joins Sidney Moncrief (1982-83 and 1983-84) as the only Milwaukee players to win Defensive Player of the Year honors.
Milwaukee held opponents to a league-low 41.3 percent shooting from the field through March 11. The club also had the best defensive rating in the NBA by allowing 101.6 points per 100 possessions. That number was 96.5 when Antetokounmpo was on the floor.
"I want to thank my teammates," Antetokounmpo said on TNT. "Without my teammates this wouldn't be possible. I know my name is on this trophy but it could have been any of these guys' names on this trophy."
Antetokounmpo also is finalist to win his second straight MVP award.
Only Chicago's Michael Jordan (1987-88) and Houston's Hakeem Olajuwon (1993-94) have been named MVP and Defensive Player of the Year in the same season.
--Field Level Media