49ers QB Brock Purdy, DE Nick Bosa out for Week 12 game vs. Packers

Purdy had been a limited participant in practice all week with right shoulder soreness

San Francisco 49ers quarterback Brock Purdy is out for Week 12's matchup with the Green Bay Packers. Defensive end Nick Bosa will not play either.

Purdy did not practice on Friday, which made his status uncertain. But head coach Kyle Shanahan officially announced he was out when meeting with reporters after practice. Brandon Allen will start at quarterback versus Green Bay.

Additionally, left tackle Trent Williams is listed as questionable with an ankle injury and will be a game-time decision, according to Shanahan.

Earlier Friday, the NFL listed Purdy as out on its injury report. He was previously listed as questionable, but has now been officially downgraded.

Bosa was also listed as out on the injury report due to hip and oblique issues. He suffered the injury in practice on Nov. 6 and played through the injury in Week 10's matchup with Tampa Bay. The pass rusher left last week's matchup with the Seahawks in the third quarter and did not return. Following the game, Bosa told reporters that he hurt his oblique while compensating for the hip injury.

Williams suffered his injury in Week 10, as well. He played against Seattle after taking a painkilling injection for his ankle, but that may have made the situation worse. The veteran offensive lineman did not participate in practice all week.

Right shoulder soreness limited Purdy in practice on Wednesday and Thursday, and he did not participate in the team's final practice session before traveling to Green Bay.

General manager John Lynch told KNBR on Friday that Purdy had an MRI and described his status for Sunday as "tenuous."

"Hopefully, he makes progress, and we can have a shot at this weekend, but we’ll see," Lynch said. "I think it’s tenuous.”

At Thursday's practice, Purdy's participation consisted of soft throws while San Francisco's other three quarterbacks went through drills with QB coach Brian Griese. Purdy stopped after approximately five minutes, had his shoulder worked on by trainers and went back to the locker room, according to reporters on the scene.

Purdy appeared to suffer the injury during last week's 20-17 loss to the Seattle Seahawks. He finished the game, yet did not make any throws over 10 yards following the hit that potentially injured him. There was no indication afterward that Purdy was hurt.

Allen is in his second season with the 49ers after seeing no action behind Purdy and Sam Darnold during the 2023-24 campaign. He played 2019 with the Denver Broncos, followed by three seasons with the Cincinnati Bengals.