Reed suffered an apparent knee and ankle injury late in the first quarter while attempting to drag his feet along the back of the end zone on a throw from quarterback Nick Mullens. Reed promptly clutched at his left leg as he tumbled toward the ground.
Kittle has been sidelined with a sprained left knee that he sustained in San Francisco's season-opening 24-20 loss to Arizona.
Moseley was injured after colliding with safety Jaquiski Tartt as the pair converged on Giants quarterback Daniel Jones after a 19-yard run. Dontae Johnson replaced Moseley, who was ruled out with a concussion.
--Field Level Media